Ontology highlight
ABSTRACT:
SUBMITTER: Denef N
PROVIDER: S-EPMC2278040 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Denef Natalie N Chen Yu Y Weeks Stephen D SD Barcelo Gail G Schüpbach Trudi T
Developmental cell 20080301 3
The polarized architecture of epithelia relies on an interplay between the cytoskeleton, the trafficking machinery, and cell-cell and cell-matrix adhesion. Specifically, contact with the basement membrane (BM), an extracellular matrix underlying the basal side of epithelia, is important for cell polarity. However, little is known about how BM proteins themselves achieve a polarized distribution. In a genetic screen in the Drosophila follicular epithelium, we identified mutations in Crag, which e ...[more]