Ontology highlight
ABSTRACT:
SUBMITTER: El Jamali A
PROVIDER: S-EPMC2278123 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
El Jamali Amina A Valente Anthony J AJ Lechleiter James D JD Gamez Maria J MJ Pearson Doran W DW Nauseef William M WM Clark Robert A RA
Free radical biology & medicine 20071208 5
We investigated the mechanism of H(2)O(2) activation of the Ca(2+)-regulated NADPH oxidase NOX5. H(2)O(2) induced a transient, dose-dependent increase in superoxide production in K562 cells expressing NOX5. Confocal studies demonstrated that the initial calcium influx generated by H(2)O(2) is amplified by a feedback mechanism involving NOX5-dependent superoxide production and H(2)O(2). H(2)O(2) NOX5 activation was inhibited by extracellular Ca(2+) chelators, a pharmacological inhibitor of c-Abl, ...[more]