Ontology highlight
ABSTRACT:
SUBMITTER: Johansen P
PROVIDER: S-EPMC2278203 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Johansen Pål P Storni Tazio T Rettig Lorna L Qiu Zhiyong Z Der-Sarkissian Ani A Smith Kent A KA Manolova Vania V Lang Karl S KS Senti Gabriela G Müllhaupt Beat B Gerlach Tilman T Speck Roberto F RF Bot Adrian A Kündig Thomas M TM
Proceedings of the National Academy of Sciences of the United States of America 20080324 13
A current paradigm in immunology is that the strength of T cell responses is governed by antigen dose, localization, and costimulatory signals. This study investigates the influence of antigen kinetics on CD8 T cell responses in mice. A fixed cumulative antigen dose was administered by different schedules to produce distinct dose-kinetics. Antigenic stimulation increasing exponentially over days was a stronger stimulus for CD8 T cells and antiviral immunity than a single dose or multiple dosing ...[more]