Selection against tandem splice sites affecting structured protein regions.
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ABSTRACT:
SUBMITTER: Hiller M
PROVIDER: S-EPMC2279118 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Selection against tandem splice sites affecting structured protein regions.
Hiller Michael M Szafranski Karol K Huse Klaus K Backofen Rolf R Platzer Matthias M
BMC evolutionary biology 20080321
<h4>Background</h4>Alternative selection of splice sites in tandem donors and acceptors is a major mode of alternative splicing. Here, we analyzed whether in-frame tandem sites leading to subtle mRNA insertions/deletions of 3, 6, or 9 nucleotides are under natural selection.<h4>Results</h4>We found multiple lines of evidence that the human protein coding sequences are under selection against such in-frame tandem splice events, indicating that these events are often deleterious. The strength of s ...[more]
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