Ontology highlight
ABSTRACT:
SUBMITTER: Vetriani C
PROVIDER: S-EPMC22826 | biostudies-literature | 1998 Oct
REPOSITORIES: biostudies-literature
Vetriani C C Maeder D L DL Tolliday N N Yip K S KS Stillman T J TJ Britton K L KL Rice D W DW Klump H H HH Robb F T FT
Proceedings of the National Academy of Sciences of the United States of America 19981001 21
The discovery of hyperthermophilic microorganisms and the analysis of hyperthermostable enzymes has established the fact that multisubunit enzymes can survive for prolonged periods at temperatures above 100 degreesC. We have carried out homology-based modeling and direct structure comparison on the hexameric glutamate dehydrogenases from the hyperthermophiles Pyrococcus furiosus and Thermococcus litoralis whose optimal growth temperatures are 100 degreesC and 88 degreesC, respectively, to determ ...[more]