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Novel simian homologues of Epstein-Barr virus.

ABSTRACT: Thirty different lymphocryptoviruses (LCV), 26 of them novel, were detected in primates by a panherpesvirus PCR assay. Nineteen LCV from chimpanzees, bonobos, gorillas, and other Old World primates were closely related to Epstein-Barr virus (EBV), the type species of the genus lymphocryptovirus. Seven LCV originating from New World primates were related to callitrichine herpesvirus 3 (CalHV-3), the first recognized New World LCV. Importantly, a second LCV from gorillas and three LCV from orangutans and gibbons were only distantly related to EBV and CalHV-3. They were tentatively assigned to a novel genogroup of Old World primate LCV. The work described in the paper may also help identify an as yet unknown human LCV.

SUBMITTER: Ehlers B

PROVIDER: S-EPMC228477 | biostudies-literature | 2003 Oct

REPOSITORIES: biostudies-literature

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Novel simian homologues of Epstein-Barr virus.

Ehlers Bernhard B Ochs Andreas A Leendertz Fabian F Goltz Michael M Boesch Christophe C Mätz-Rensing Kerstin K

Journal of virology 20031001 19

Thirty different lymphocryptoviruses (LCV), 26 of them novel, were detected in primates by a panherpesvirus PCR assay. Nineteen LCV from chimpanzees, bonobos, gorillas, and other Old World primates were closely related to Epstein-Barr virus (EBV), the type species of the genus lymphocryptovirus. Seven LCV originating from New World primates were related to callitrichine herpesvirus 3 (CalHV-3), the first recognized New World LCV. Importantly, a second LCV from gorillas and three LCV from orangut ...[more]

PMID: 12970457

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