Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC2286586 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Li Xuemei X Liu Xueqi X Lou Zhiyong Z Duan Xin X Wu Hao H Liu Yiwei Y Rao Zihe Z
Protein science : a publication of the Protein Society 20040930 11
Human coactosin-like protein (CLP) shares high homology with coactosin, a filamentous (F)-actin binding protein, and interacts with 5LO and F-actin. As a tumor antigen, CLP is overexpressed in tumor tissue cells or cell lines, and the encoded epitopes can be recognized by cellular and humoral immune systems. To gain a better understanding of its various functions and interactions with related proteins, the crystal structure of CLP expressed in Escherichia coli has been determined to 1.9 A resolu ...[more]