Ontology highlight
ABSTRACT:
SUBMITTER: Fitzkee NC
PROVIDER: S-EPMC2286724 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Fitzkee Nicholas C NC Rose George D GD
Protein science : a publication of the Protein Society 20040206 3
Using only hard-sphere repulsion, we investigated short polyalanyl chains for the presence of sterically imposed conformational constraints beyond the dipeptide level. We found that a central residue in a helical peptide cannot adopt dihedral angles from strand regions without encountering a steric collision. Consequently, an alpha-helical segment followed by a beta-strand segment must be connected by an intervening linker. This restriction was validated both by simulations and by seeking violat ...[more]