Ontology highlight
ABSTRACT:
SUBMITTER: Weis SM
PROVIDER: S-EPMC2287283 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Weis Sara M SM Lim Ssang-Taek ST Lutu-Fuga Kimberly M KM Barnes Leo A LA Chen Xiao Lei XL Göthert Joachim R JR Shen Tang-Long TL Guan Jun-Lin JL Schlaepfer David D DD Cheresh David A DA
The Journal of cell biology 20080401 1
Focal adhesion kinase (FAK) plays a critical role during vascular development because knockout of FAK in endothelial cells (ECs) is embryonic lethal. Surprisingly, tamoxifen-inducible conditional knockout of FAK in adult blood vessels (inducible EC-specific FAK knockout [i-EC-FAK-KO]) produces no vascular phenotype, and these animals are capable of developing a robust growth factor-induced angiogenic response. Although angiogenesis in wild-type mice is suppressed by pharmacological inhibition of ...[more]