FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils.
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ABSTRACT:
SUBMITTER: Zandomeneghi G
PROVIDER: S-EPMC2287307 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
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FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils.
Zandomeneghi Giorgia G Krebs Mark R H MR McCammon Margaret G MG Fändrich Marcus M
Protein science : a publication of the Protein Society 20041110 12
The presence of beta-sheets in the core of amyloid fibrils raised questions as to whether or not beta-sheet-containing proteins, such as transthyretin, are predisposed to form such fibrils. However, we show here that the molecular structure of amyloid fibrils differs more generally from the beta-sheets in native proteins. This difference is evident from the amide I region of the infrared spectrum and relates to the distribution of the phi/psi dihedral angles within the Ramachandran plot, the ave ...[more]
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