A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy.
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ABSTRACT:
SUBMITTER: Yoneda Y
PROVIDER: S-EPMC2288489 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy.
Yoneda Yoshiyuki Y Steiniger Sebastian C J SC Capková Katerina K Mee Jenny M JM Liu Ying Y Kaufmann Gunnar F GF Janda Kim D KD
Bioorganic & medicinal chemistry letters 20080119 5
Tumor targeting peptides are promising vehicles for site-directed cancer therapy. Pep42, a cyclic 13-mer oligopeptide that specifically binds to glucose-regulated protein 78 (GRP78) and internalized into cancer cells, represents an excellent vehicle for tumor cell-specific chemotherapy. Here, we report the synthesis and evaluation of Pep42-prodrug conjugates that contain a cathepsin B-cleavable linker, resulting in the traceless release of drug inside the cancer cells. ...[more]
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