Ontology highlight
ABSTRACT:
SUBMITTER: van der Horst EH
PROVIDER: S-EPMC2288540 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
van der Horst Edward Htun EH Frank Brendon T BT Chinn Lawrence L Coxon Angela A Li Shyun S Polesso Fanny F Slavin Anthony A Ruefli-Brasse Astrid A Wesche Holger H
Neoplasia (New York, N.Y.) 20080401 4
Midkine (MDK) is a heparin-binding growth factor involved in growth, survival, migration, and differentiation of various target cells and dysregulation of MDK signaling is implicated in a variety of inflammatory diseases and cancers. Although MDK has been reported to act on endothelial cells and to have proangiogenic effects, the exact role of MDK in angiogenesis is poorly defined. Here, we report that MDK is actually a modulator of angiogenesis and that it can abrogate the vascular endothelial ...[more]