Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC2288703 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Liu Zhaoyang Z Schey Kevin L KL
Journal of the American Society for Mass Spectrometry 20070620 2
Top down proteomics in a TOF-TOF instrument was further explored by examining the fragmentation of multiply charged precursors ions generated by matrix-assisted laser desorption ionization. Evaluation of sample preparation conditions allowed selection of solvent/matrix conditions and sample deposition methods to produce sufficiently abundant doubly and triply charged precursor ions for subsequent CID experiments. As previously reported, preferential cleavage was observed at sites C-terminal to a ...[more]