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Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium.


ABSTRACT: Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lymphomagenesis.

SUBMITTER: Ekstrom Smedby K 

PROVIDER: S-EPMC2288717 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature

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Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium.

Ekström Smedby Karin K   Vajdic Claire M CM   Falster Michael M   Engels Eric A EA   Martínez-Maza Otoniel O   Turner Jennifer J   Hjalgrim Henrik H   Vineis Paolo P   Seniori Costantini Adele A   Bracci Paige M PM   Holly Elizabeth A EA   Willett Eleanor E   Spinelli John J JJ   La Vecchia Carlo C   Zheng Tongzhang T   Becker Nikolaus N   De Sanjosé Silvia S   Chiu Brian C-H BC   Dal Maso Luigino L   Cocco Pierluigi P   Maynadié Marc M   Foretova Lenka L   Staines Anthony A   Brennan Paul P   Davis Scott S   Severson Richard R   Cerhan James R JR   Breen Elizabeth C EC   Birmann Brenda B   Grulich Andrew E AE   Cozen Wendy W  

Blood 20080208 8


Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increa  ...[more]

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