Ontology highlight
ABSTRACT:
SUBMITTER: Grassart A
PROVIDER: S-EPMC2288760 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Grassart Alexandre A Dujeancourt Annick A Lazarow Paul B PB Dautry-Varsat Alice A Sauvonnet Nathalie N
EMBO reports 20080314 4
There are several endocytic pathways, which are either dependent on or independent of clathrin. This study focuses on a poorly characterized mechanism-clathrin- and caveolae-independent endocytosis-used by the interleukin-2 receptor beta (IL-2R beta). We address the question of its regulation in comparison with the clathrin-dependent pathway. First, we show that Ras-related C3 botulinum toxin substrate 1 (Rac1) is specifically required for IL-2R beta entry, and we identify p21-activated kinases ...[more]