Ontology highlight
ABSTRACT:
SUBMITTER: Sinzelle L
PROVIDER: S-EPMC2290759 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Sinzelle Ludivine L Kapitonov Vladimir V VV Grzela Dawid P DP Jursch Tobias T Jurka Jerzy J Izsvák Zsuzsanna Z Ivics Zoltán Z
Proceedings of the National Academy of Sciences of the United States of America 20080313 12
Ancient, inactive copies of transposable elements of the PIF/Harbinger superfamily have been described in vertebrates. We reconstructed components of the Harbinger3_DR transposon in zebrafish, including a transposase and a second, transposon-encoded protein that has a Myb-like trihelix domain. The reconstructed Harbinger transposon shows efficient cut-and-paste transposition in human cells and preferentially inserts into a 15-bp consensus target sequence. The Myb-like protein is required for tra ...[more]