Ontology highlight
ABSTRACT:
SUBMITTER: Schluter C
PROVIDER: S-EPMC2291407 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Schluter Cayetana C Lam Karen K Y KK Brumm Jochen J Wu Bella W BW Saunders Matthew M Stevens Tom H TH Bryan Jennifer J Conibear Elizabeth E
Molecular biology of the cell 20080123 4
Endosomal transport is critical for cellular processes ranging from receptor down-regulation and retroviral budding to the immune response. A full understanding of endosome sorting requires a comprehensive picture of the multiprotein complexes that orchestrate vesicle formation and fusion. Here, we use unsupervised, large-scale phenotypic analysis and a novel computational approach for the global identification of endosomal transport factors. This technique effectively identifies components of k ...[more]