Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation.
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ABSTRACT:
SUBMITTER: Lopez-Aviles S
PROVIDER: S-EPMC2291412 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Publications
Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation.
López-Avilés Sandra S Lambea Eva E Moldón Alberto A Grande Maribel M Fajardo Alba A Rodríguez-Gabriel Miguel A MA Hidalgo Elena E Aligue Rosa R
Molecular biology of the cell 20080213 4
Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. The Schizosaccharomyces pombe SAPK Sty1/Spc1 orchestrates general changes in gene expression in response to diverse forms of cytotoxic stress. Here we show that Sty1/Spc1 is bound to its target, the Srk1 kinase, when the signaling pathway is inactive. In response to stress, Sty1/Spc1 phosphorylates Srk1 at threonine 463 of the regulatory domain, inducing both a ...[more]
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