Ontology highlight
ABSTRACT:
SUBMITTER: Couper KN
PROVIDER: S-EPMC2291447 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Couper Kevin N KN Blount Daniel G DG Wilson Mark S MS Hafalla Julius C JC Belkaid Yasmine Y Kamanaka Masahito M Flavell Richard A RA de Souza J Brian JB Riley Eleanor M EM
PLoS pathogens 20080229 2
The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective pro-inflammatory response can lead to unrestricted parasite replication, whilst failure to regulate this response leads to the development of severe immunopathology. IL-10 and TGF-beta are known to be important components of the regulatory response, but the cellular source of these cytokines is still unknown. Here we have examined the role o ...[more]