Ontology highlight
ABSTRACT:
SUBMITTER: Nie Y
PROVIDER: S-EPMC2292218 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Nie Yuchun Y Han Yoon-Chi YC Zou Yong-Rui YR
The Journal of experimental medicine 20080331 4
The quiescence of hematopoietic stem cells (HSCs) is critical for preserving a lifelong steady pool of HSCs to sustain the highly regenerative hematopoietic system. It is thought that specialized niches in which HSCs reside control the balance between HSC quiescence and self-renewal, yet little is known about the extrinsic signals provided by the niche and how these niche signals regulate such a balance. We report that CXCL12 produced by bone marrow (BM) stromal cells is not only the major chemo ...[more]