Ontology highlight
ABSTRACT:
SUBMITTER: Wiedemeyer R
PROVIDER: S-EPMC2292238 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Wiedemeyer Ruprecht R Brennan Cameron C Heffernan Timothy P TP Xiao Yonghong Y Mahoney John J Protopopov Alexei A Zheng Hongwu H Bignell Graham G Furnari Frank F Cavenee Webster K WK Hahn William C WC Ichimura Koichi K Collins V Peter VP Chu Gerald C GC Stratton Michael R MR Ligon Keith L KL Futreal P Andrew PA Chin Lynda L
Cancer cell 20080401 4
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Functional reconstitution of p18(INK4C) in GBM cells null for both p16(INK4A) and p18(INK4C) resulted in impaired cell-cycle progression and tumorigenic potential. Conversely, RNAi-mediated depletion of p18(INK4C) in p16(INK4A)-deficient primary astrocytes or established GBM cells enhanc ...[more]