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Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp.


ABSTRACT: Carbapenem resistance results mostly from the expression of acquired carbapenem-hydrolyzing oxacillinases in Acinetobacter baumannii. The bla OXA-23 oxacillinase gene is increasingly reported worldwide and may represent an emerging threat. Our goal was to identify the progenitor of that carbapenemase gene. A collection of 50 Acinetobacter sp. strains corresponding to several Acinetobacter species was screened for bla(OXA-23)-like genes by PCR and hybridization techniques. Five Acinetobacter radioresistens isolates that were susceptible to carbapenems harbored chromosomally encoded bla OXA-23-like genes. A similar plasmid backbone was identified in several bla OXA-23-positive A. baumannii and A. radioresistens isolates, further strengthening the vectors of exchanges for these bla OXA-23-like genes. Therefore, A. radioresistens, a commensal bacterial species which is identified on the skin of hospitalized and healthy patients (a property shared with A. baumannii), was identified as the source of the bla OXA-23 gene.

SUBMITTER: Poirel L 

PROVIDER: S-EPMC2292503 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature

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Acinetobacter radioresistens as a silent source of carbapenem resistance for Acinetobacter spp.

Poirel Laurent L   Figueiredo Samy S   Cattoir Vincent V   Carattoli Alessandra A   Nordmann Patrice P  

Antimicrobial agents and chemotherapy 20080114 4


Carbapenem resistance results mostly from the expression of acquired carbapenem-hydrolyzing oxacillinases in Acinetobacter baumannii. The bla OXA-23 oxacillinase gene is increasingly reported worldwide and may represent an emerging threat. Our goal was to identify the progenitor of that carbapenemase gene. A collection of 50 Acinetobacter sp. strains corresponding to several Acinetobacter species was screened for bla(OXA-23)-like genes by PCR and hybridization techniques. Five Acinetobacter radi  ...[more]

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