Dataset Information

Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans.

ABSTRACT: The basis for gender influences on allergen-specific IgEs is unclear.To perform regular and sex-stratified genomewide linkage analyses of IgE to each of three allergens (Ascaris lumbricoides, Blatella germanica [German cockroach]), and Dermatophagoides pteronyssinus [dust mite]) and to conduct an association study of a candidate gene in a linked genomic region.Genomewide linkage analyses of allergen-specific IgEs were conducted in 653 members of eight large families of Costa Rican children with asthma. An analysis of the association between single-nucleotide polymorphisms in thymic stromal lymphopoietin (TSLP) and IgE measurements was conducted in 417 parent-child trios in Costa Rica. Significant results were replicated in 470 families of white children in the Childhood Asthma Management Program (CAMP).Among all subjects, there was suggestive evidence of linkage (LOD >/= 2.72) to IgE to Ascaris (on chromosome 7q) and IgE to dust mite (on chromosomes 7p and 12q). In a sex-stratified analysis, there was significant evidence of linkage to IgE to cockroach on chromosome 5q23 (peak LOD, 4.14 at 127 cM) in female subjects. TSLP is located within the 1.5 LOD-unit support interval for this linkage peak and has female-specific effects on lung disease in mice. In a sex-stratified analysis, the T allele of single-nucleotide polymorphism rs2289276 in TSLP was associated with reductions in IgE to cockroach (in Costa Rican girls) and total IgE (in girls in Costa Rica and in CAMP; P value for sex-by-genotype interaction, <0.01 in both studies).Consistent with findings in murine models, a variant in TSLP may have female-specific effects on allergic phenotypes.

SUBMITTER: Hunninghake GM

PROVIDER: S-EPMC2292826 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans.

Hunninghake Gary M GM Lasky-Su Jessica J Soto-Quirós Manuel E ME Avila Lydiana L Liang Catherine C Lake Stephen L SL Hudson Thomas J TJ Spesny Mitzi M Fournier Eduardo E Sylvia Jody S JS Freimer Nelson B NB Klanderman Barbara J BJ Raby Benjamin A BA Celedón Juan C JC

American journal of respiratory and critical care medicine 20080131 8

<h4>Rationale</h4>The basis for gender influences on allergen-specific IgEs is unclear.<h4>Objectives</h4>To perform regular and sex-stratified genomewide linkage analyses of IgE to each of three allergens (Ascaris lumbricoides, Blatella germanica [German cockroach]), and Dermatophagoides pteronyssinus [dust mite]) and to conduct an association study of a candidate gene in a linked genomic region.<h4>Methods</h4>Genomewide linkage analyses of allergen-specific IgEs were conducted in 653 members ...[more]

PMID: 18244952

Similar Datasets

Project description:UnlabelledBackgroundLittle is known about adult health and mortality relationships outside high-income nations, partly because few datasets have contained biomarker data in representative populations. Our objective is to determine the prognostic value of biomarkers with respect to total and cardiovascular mortality in an elderly population of a middle-income country, as well as the extent to which they mediate the effects of age and sex on mortality.MethodsThis is a prospective population-based study in a nationally representative sample of elderly Costa Ricans. Baseline interviews occurred mostly in 2005 and mortality follow-up went through December 2010. Sample size after excluding observations with missing values: 2,313 individuals and 564 deaths.Main outcomeprospective death rate ratios for 22 baseline biomarkers, which were estimated with hazard regression models.ResultsBiomarkers significantly predict future death above and beyond demographic and self-reported health conditions. The studied biomarkers account for almost half of the effect of age on mortality. However, the sex gap in mortality became several times wider after controlling for biomarkers. The most powerful predictors were simple physical tests: handgrip strength, pulmonary peak flow, and walking speed. Three blood tests also predicted prospective mortality: C-reactive protein (CRP), glycated hemoglobin (HbA1c), and dehydroepiandrosterone sulfate (DHEAS). Strikingly, high blood pressure (BP) and high total cholesterol showed little or no predictive power. Anthropometric measures also failed to show significant mortality effects.ConclusionsThis study adds to the growing evidence that blood markers for CRP, HbA1c, and DHEAS, along with organ-specific functional reserve indicators (handgrip, walking speed, and pulmonary peak flow), are valuable tools for identifying vulnerable elderly. The results also highlight the need to better understand an anomaly noted previously in other settings: despite the continued medical focus on drugs for BP and cholesterol, high levels of BP and cholesterol have little predictive value of mortality in this elderly population.

Dataset Information

Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans.

Publications

Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets