Rapid detection of triazole antifungal resistance in Aspergillus fumigatus.
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ABSTRACT:
SUBMITTER: Garcia-Effron G
PROVIDER: S-EPMC2292958 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Publications
Rapid detection of triazole antifungal resistance in Aspergillus fumigatus.
Garcia-Effron Guillermo G Dilger Amanda A Alcazar-Fuoli Laura L Park Steven S Mellado Emilia E Perlin David S DS
Journal of clinical microbiology 20080130 4
Triazole resistance in Aspergillus fumigatus is an uncommon but rising phenomenon. Susceptibility testing is rarely performed and can take 48 h or longer, which is an impediment to effective therapy. Molecular diagnostic probing of well-defined resistance mechanisms, which serve as surrogate markers, provides an alternative approach to rapidly (within hours) and efficiently identify resistant strains. The mechanisms of triazole resistance in A. fumigatus are limited to amino acid substitutions i ...[more]
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