Novel monofunctional histidinol-phosphate phosphatase of the DDDD superfamily of phosphohydrolases.
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ABSTRACT:
SUBMITTER: Lee HS
PROVIDER: S-EPMC2293174 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
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Novel monofunctional histidinol-phosphate phosphatase of the DDDD superfamily of phosphohydrolases.
Lee Hyun Sook HS Cho Yona Y Lee Jung-Hyun JH Kang Sung Gyun SG
Journal of bacteriology 20080125 7
The TON_0887 gene was identified as the missing histidinol-phosphate phosphatase (HolPase) in the hyperthermophilic archaeon "Thermococcus onnurineus" NA1. The protein contained conserved motifs of the DDDD superfamily of phosphohydrolase, and the recombinantly expressed protein exhibited strong HolPase activity. In this study, we functionally assessed for the first time the monofunctional DDDD-type HolPase, which is organized in the gene cluster. ...[more]
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