Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelope.
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ABSTRACT:
SUBMITTER: Penn-Nicholson A
PROVIDER: S-EPMC2293309 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
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Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelope.
Penn-Nicholson Adam A Han Dong P DP Kim Soon J SJ Park Hanna H Ansari Rais R Montefiori David C DC Cho Michael W MW
Virology 20071219 2
Human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein gp41 is targeted by broadly-reactive neutralizing antibodies 2F5 and 4E10, making it an attractive target for vaccine development. To better assess immunogenic properties of gp41, we generated five soluble glutathione S-transferase fusion proteins encompassing C-terminal 30, 64, 100, 142, or 172 (full-length) amino acids of gp41 ectodomain from M group consensus envelope sequence. Antibody responses in HIV-1-infected patients ...[more]
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