Gene expression changes after seizure preconditioning in the three major hippocampal cell layers.
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ABSTRACT:
SUBMITTER: Borges K
PROVIDER: S-EPMC2295285 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Publications
Gene expression changes after seizure preconditioning in the three major hippocampal cell layers.
Borges Karin K Shaw Renee R Dingledine Raymond R
Neurobiology of disease 20070118 1
Rodents experience hippocampal damage after status epilepticus (SE) mainly in pyramidal cells while sparing the dentate granule cell layer (DGCL). Hippocampal damage was prevented in rats that had been preconditioned by brief seizures on 2 consecutive days before SE. To identify neuroprotective genes and biochemical pathways changed after preconditioning we compared the effect of preconditioning on gene expression in the CA1 and CA3 pyramidal and DGCLs, harvested by laser capture microscopy. In ...[more]
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