Ontology highlight
ABSTRACT:
SUBMITTER: Kuismanen SA
PROVIDER: S-EPMC23037 | biostudies-literature | 1999 Oct
REPOSITORIES: biostudies-literature
Kuismanen S A SA Holmberg M T MT Salovaara R R Schweizer P P Aaltonen L A LA de La Chapelle A A Nyström-Lahti M M Peltomäki P P
Proceedings of the National Academy of Sciences of the United States of America 19991001 22
Aberrant DNA methylation is a common phenomenon in human cancer, but its patterns, causes, and consequences are poorly defined. Promoter methylation of the DNA mismatch repair gene MutL homologue (MLH1) has been implicated in the subset of colorectal cancers that shows microsatellite instability (MSI). The present analysis of four MspI/HpaII sites at the MLH1 promoter region in a series of 89 sporadic colorectal cancers revealed two main methylation patterns that closely correlated with the MSI ...[more]