Ontology highlight
ABSTRACT:
SUBMITTER: Otte L
PROVIDER: S-EPMC2312455 | biostudies-literature | 2003 Mar
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20030301 3
WW domains mediate protein-protein interactions in a number of different cellular functions by recognizing proline-containing peptide sequences. We determined peptide recognition propensities for 42 WW domains using NMR spectroscopy and peptide library screens. As potential ligands, we studied both model peptides and peptides based on naturally occurring sequences, including phosphorylated residues. Thirty-two WW domains were classified into six groups according to detected ligand recognition pr ...[more]