Ontology highlight
ABSTRACT:
SUBMITTER: Amstutz B
PROVIDER: S-EPMC2323250 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Amstutz Beat B Gastaldelli Michele M Kälin Stefan S Imelli Nicola N Boucke Karin K Wandeler Eliane E Mercer Jason J Hemmi Silvio S Greber Urs F UF
The EMBO journal 20080306 7
Endocytosis supports cell communication, growth, and pathogen infection. The species B human adenovirus serotype 3 (Ad3) is associated with epidemic conjunctivitis, and fatal respiratory and systemic disease. Here we show that Ad3 uses dynamin-independent endocytosis for rapid infectious entry into epithelial and haematopoietic cells. Unlike Ad5, which uses dynamin-dependent endocytosis, Ad3 endocytosis spatially and temporally coincided with enhanced fluid-phase uptake. It was sensitive to macr ...[more]