Ontology highlight
ABSTRACT:
SUBMITTER: Burkhardt P
PROVIDER: S-EPMC2323264 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
The EMBO journal 20080313 7
Sec1/Munc18-like (SM) proteins functionally interact with SNARE proteins in vesicular fusion. Despite their high sequence conservation, structurally disparate binding modes for SM proteins with syntaxins have been observed. Several SM proteins appear to bind only to a short peptide present at the N terminus of syntaxin, designated the N-peptide, while Munc18a binds to a 'closed' conformation formed by the remaining portion of syntaxin 1a. Here, we show that the syntaxin 16 N-peptide binds to the ...[more]