Ontology highlight
ABSTRACT:
SUBMITTER: Das SK
PROVIDER: S-EPMC2323364 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
BMC medical genetics 20080317
<h4>Background</h4>ARNT, a member of the basic helix-loop-helix family of transcription factors, is located on human chromosome 1q21-q24, a region which showed well replicated linkage to type 2 diabetes. We hypothesized that common polymorphisms in the ARNT gene might increase the susceptibility to type 2 diabetes through impaired glucose-stimulated insulin secretion.<h4>Methods</h4>We selected 9 single nucleotide polymorphisms to tag common variation across the ARNT gene. Additionally we search ...[more]