Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients.
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ABSTRACT:
SUBMITTER: Yao K
PROVIDER: S-EPMC2323568 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Publications
Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients.
Yao Karen K Gagnon Susan S Akhyani Nahid N Williams Elizabeth E Fotheringham Julie J Frohman Elliot E Stuve Olaf O Monson Nancy N Racke Michael K MK Jacobson Steven S
PloS one 20080430 4
The alpha(4) integrin antagonist natalizumab was shown to be effective in patients with immune-mediated disorders but was unexpectedly associated with JC polyomavirus associated progressive multifocal leukoencephalopathy (PML) in two multiple sclerosis (MS) and one Crohn's disease patients. Impaired immune surveillance due to natalizumab treatment may have contributed to the JCV reactivation. As HHV-6 has been suggested to play a role in MS, we asked whether this virus could also have been react ...[more]
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