Ontology highlight
ABSTRACT:
SUBMITTER: Lepesheva GI
PROVIDER: S-EPMC2324070 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Chemistry & biology 20071101 11
Sterol 14alpha-demethylases (CYP51) serve as primary targets for antifungal drugs, and specific inhibition of CYP51s in protozoan parasites Trypanosoma brucei (TB) and Trypanosoma cruzi (TC) might provide an effective treatment strategy for human trypanosomiases. Primary inhibitor selection is based initially on the cytochrome P450 spectral response to ligand binding. Ligands that demonstrate strongest binding parameters were examined as inhibitors of reconstituted TB and TC CYP51 activity in vi ...[more]