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Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.

ABSTRACT: In mice, recent thymic emigrants (RTEs) make up a large part of the naïve T cell pool and have been suggested to be a distinct short-lived pool. In humans, however, the life span and number of RTEs are unknown. Although (2)H(2)O labeling in young mice showed high thymic-dependent daily naïve T cell production, long term up- and down-labeling with (2)H(2)O in human adults revealed a low daily production of naïve T cells. Using mathematical modeling, we estimated human naïve CD4 and CD8 T cell half-lives of 4.2 and 6.5 years, respectively, whereas memory CD4 and CD8 T cells had half-lives of 0.4 and 0.7 year. The estimated half-life of recently produced naïve T cells was much longer than these average half-lives. Thus, our data are incompatible with a substantial short-lived RTE population in human adults and suggest that the few naïve T cells that are newly produced are preferentially incorporated in the peripheral pool.

SUBMITTER: Vrisekoop N

PROVIDER: S-EPMC2329696 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature

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Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.

Vrisekoop Nienke N den Braber Ineke I de Boer Anne Bregje AB Ruiter An F C AF Ackermans Mariëtte T MT van der Crabben Saskia N SN Schrijver Elise H R EH Spierenburg Gerrit G Sauerwein Hans P HP Hazenberg Mette D MD de Boer Rob J RJ Miedema Frank F Borghans José A M JA Tesselaar Kiki K

Proceedings of the National Academy of Sciences of the United States of America 20080417 16

In mice, recent thymic emigrants (RTEs) make up a large part of the naïve T cell pool and have been suggested to be a distinct short-lived pool. In humans, however, the life span and number of RTEs are unknown. Although (2)H(2)O labeling in young mice showed high thymic-dependent daily naïve T cell production, long term up- and down-labeling with (2)H(2)O in human adults revealed a low daily production of naïve T cells. Using mathematical modeling, we estimated human naïve CD4 and CD8 T cell hal ...[more]

PMID: 18420820

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Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.

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Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.

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