Ontology highlight
ABSTRACT:
SUBMITTER: Wen Y
PROVIDER: S-EPMC2329816 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Wen Yi Y Yu W Haung WH Maloney Bryan B Bailey Jason J Ma Junrong J Marié Isabelle I Maurin Thomas T Wang Lili L Figueroa Helen H Herman Mathieu M Krishnamurthy Pavan P Liu Li L Planel Emmanuel E Lau Lit-Fui LF Lahiri Debomoy K DK Duff Karen K
Neuron 20080301 5
Cyclin-dependent kinase 5 (cdk5) has been implicated in Alzheimer's disease (AD) pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription (STAT1/3) was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BAC ...[more]