Ontology highlight
ABSTRACT:
SUBMITTER: Shimizu N
PROVIDER: S-EPMC2330061 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Shimizu Natsumi N Noda Shinichi S Katayama Kazufumi K Ichikawa Hitoshi H Kodama Hiroaki H Miyoshi Hiroyuki H
International journal of hematology 20080304 3
Although coculture of hematopoietic stem cells (HSCs) with stromal cells is a useful system to study hematopoiesis in the niche, little is known regarding the precise cellular and molecular mechanisms of maintaining HSCs through cell-cell interactions. The murine preadipose stromal cell line MC3T3-G2/PA6 (PA6) has been demonstrated to support HSCs in vitro. In this study, microarray analysis was performed on PA6 cells and HSC-nonsupporting PA6 subclone cells to identify genes responsible for sup ...[more]