Ontology highlight
ABSTRACT:
SUBMITTER: Barinka C
PROVIDER: S-EPMC2330195 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Barinka Cyril C Starkova Jana J Konvalinka Jan J Lubkowski Jacek J
Acta crystallographica. Section F, Structural biology and crystallization communications 20070213 Pt 3
Human glutamate carboxypeptidase II (GCPII; EC 3.4.17.21) is an established marker for prostate-cancer diagnosis as well as a candidate therapeutic target for the treatment of diverse pathologies that involve glutamatergic transmission. Structural data on GCPII are thus valuable for the design and optimization of GCPII-specific inhibitors and diagnostic probes. The currently available structure of ligand-free GCPII was refined to a resolution of 3.5 A. This work reports the structure of the prot ...[more]