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Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus.


ABSTRACT: Using single-wavelength anomalous dispersion data obtained from a gold-derivatized crystal, the X-ray crystal structure of the protein 067745_AQUAE from the prokaryotic organism Aquifex aeolicus has been determined to a resolution of 2.0 A. Amino-acid residues 1-371 of the 44 kDa protein were identified by Pfam as an HD domain and a member of the metal-dependent phosphohydrolase superfamily (accession No. PF01966). Although three families from this large and diverse group of enzymatic proteins are represented in the PDB, the structure of 067745_AQUAE reveals a unique fold that is unlike the others and that is likely to represent a new subfamily, further organizing the families and characterizing the proteins. Data are presented that provide the first insights into the structural organization of the proteins within this clan and a distal alternative GDP-binding domain outside the metal-binding active site is proposed.

SUBMITTER: Oganesyan V 

PROVIDER: S-EPMC2335016 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature

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Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus.

Oganesyan Vaheh V   Adams Paul D PD   Jancarik Jarmila J   Kim Rosalind R   Kim Sung-Hou SH  

Acta crystallographica. Section F, Structural biology and crystallization communications 20070428 Pt 5


Using single-wavelength anomalous dispersion data obtained from a gold-derivatized crystal, the X-ray crystal structure of the protein 067745_AQUAE from the prokaryotic organism Aquifex aeolicus has been determined to a resolution of 2.0 A. Amino-acid residues 1-371 of the 44 kDa protein were identified by Pfam as an HD domain and a member of the metal-dependent phosphohydrolase superfamily (accession No. PF01966). Although three families from this large and diverse group of enzymatic proteins a  ...[more]

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