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A structural insight into lead neurotoxicity and calmodulin activation by heavy metals.

ABSTRACT: Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans.

SUBMITTER: Kursula P

PROVIDER: S-EPMC2335165 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature

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A structural insight into lead neurotoxicity and calmodulin activation by heavy metals.

Kursula Petri P Majava Viivi V

Acta crystallographica. Section F, Structural biology and crystallization communications 20070728 Pt 8

Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neur ...[more]

PMID: 17671360

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