Ontology highlight
ABSTRACT:
SUBMITTER: Guipaud O
PROVIDER: S-EPMC23419 | biostudies-literature | 1997 Sep
REPOSITORIES: biostudies-literature
Guipaud O O Marguet E E Noll K M KM de la Tour C B CB Forterre P P
Proceedings of the National Academy of Sciences of the United States of America 19970901 20
Like all hyperthermophiles yet tested, the bacterium Thermotoga maritima contains a reverse gyrase. Here we show that it contains also a DNA gyrase. The genes top2A and top2B encoding the two subunits of a DNA gyrase-like enzyme have been cloned and sequenced. The Top2A (type II DNA topoisomerase A protein) is more similar to GyrA (DNA gyrase A protein) than to ParC [topoisomerase IV (Topo IV) C protein]. The difference is especially striking at the C-terminal domain, which differentiates DNA gy ...[more]