Ontology highlight
ABSTRACT:
SUBMITTER: Tomasson MH
PROVIDER: S-EPMC2343607 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Tomasson Michael H MH Xiang Zhifu Z Walgren Richard R Zhao Yu Y Kasai Yumi Y Miner Tracie T Ries Rhonda E RE Lubman Olga O Fremont Daved H DH McLellan Michael D MD Payton Jacqueline E JE Westervelt Peter P DiPersio John F JF Link Daniel C DC Walter Matthew J MJ Graubert Timothy A TA Watson Mark M Baty Jack J Heath Sharon S Shannon William D WD Nagarajan Rakesh R Bloomfield Clara D CD Mardis Elaine R ER Wilson Richard K RK Ley Timothy J TJ
Blood 20080212 9
Activating mutations in tyrosine kinase (TK) genes (eg, FLT3 and KIT) are found in more than 30% of patients with de novo acute myeloid leukemia (AML); many groups have speculated that mutations in other TK genes may be present in the remaining 70%. We performed high-throughput resequencing of the kinase domains of 26 TK genes (11 receptor TK; 15 cytoplasmic TK) expressed in most AML patients using genomic DNA from the bone marrow (tumor) and matched skin biopsy samples ("germline") from 94 pati ...[more]