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SOS induction by stabilized topoisomerase IA cleavage complex occurs via the RecBCD pathway.

ABSTRACT: Accumulation of mutant topoisomerase I cleavage complex can lead to SOS induction and cell death in Escherichia coli. The single-stranded break associated with mutant topoisomerase I cleavage complex is converted to double-stranded break, which then is processed by the RecBCD pathway, followed by association of RecA with the single-stranded DNA.

SUBMITTER: Sutherland JH

PROVIDER: S-EPMC2347382 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature

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SOS induction by stabilized topoisomerase IA cleavage complex occurs via the RecBCD pathway.

Sutherland Jeanette H JH Cheng Bokun B Liu I-Fen IF Tse-Dinh Yuk-Ching YC

Journal of bacteriology 20080229 9

Accumulation of mutant topoisomerase I cleavage complex can lead to SOS induction and cell death in Escherichia coli. The single-stranded break associated with mutant topoisomerase I cleavage complex is converted to double-stranded break, which then is processed by the RecBCD pathway, followed by association of RecA with the single-stranded DNA. ...[more]

PMID: 18310346

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