Ontology highlight
ABSTRACT:
SUBMITTER: Simmons LA
PROVIDER: S-EPMC2350196 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Simmons Lyle A LA Davies Bryan W BW Grossman Alan D AD Walker Graham C GC
Molecular cell 20080201 3
MutS homologs function in several cellular pathways including mismatch repair (MMR), the process by which mismatches introduced during DNA replication are corrected. We demonstrate that the C terminus of Bacillus subtilis MutS is necessary for an interaction with beta clamp. This interaction is required for MutS-GFP focus formation in response to mismatches. Reciprocally, we show that a mutant of the beta clamp causes elevated mutation frequencies and is reduced for MutS-GFP focus formation. Mut ...[more]