Ontology highlight
ABSTRACT:
SUBMITTER: Bodmer D
PROVIDER: S-EPMC2360521 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Bodmer D D Ligtenberg M J L MJ van der Hout A H AH Gloudemans S S Ansink K K Oosterwijk J C JC Hoogerbrugge N N
British journal of cancer 20060815 6
To establish an efficient, reliable and easy to apply risk assessment tool to select families with breast and/or ovarian cancer patients for BRCA mutation testing, using available probability models. In a retrospective study of 263 families with breast and/or ovarian cancer patients, the utility of the Frank (Myriad), Gilpin (family history assessment tool) and Evans (Manchester) model was analysed, to select 49 BRCA mutation-positive families. For various cutoff levels and combinations, the sen ...[more]