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Evaluating the role of human papillomaviruses in conjunctival neoplasia.


ABSTRACT: Mucosal, cutaneous and Epidermodysplasia verruciformis (EV)-related human papillomaviruses (HPVs) were searched by broad-spectrum PCR in 86 conjunctival neoplasia biopsies and 63 conjunctival non-neoplastic control tissue from Ugandan subjects. Seven different EV-related HPV types, including a putative new HPV, and two mucosal HPVs were detected in 25% (14 out of 56) of HIV-positive, in 10% (three out of 30) of HIV-negative conjunctival neoplasia samples, and rarely (0-1.6%) in control subjects. The absence of high-risk HPVs and the low detection frequency of EV-related HPV types in more advanced tumour stages (10%) raise doubts about their role in conjunctival carcinomas.

SUBMITTER: Tornesello ML 

PROVIDER: S-EPMC2361142 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature

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Evaluating the role of human papillomaviruses in conjunctival neoplasia.

Tornesello M L ML   Duraturo M L ML   Waddell K M KM   Biryahwaho B B   Downing R R   Balinandi S S   Lucas S B SB   Buonaguro L L   Buonaguro F M FM  

British journal of cancer 20060201 3


Mucosal, cutaneous and Epidermodysplasia verruciformis (EV)-related human papillomaviruses (HPVs) were searched by broad-spectrum PCR in 86 conjunctival neoplasia biopsies and 63 conjunctival non-neoplastic control tissue from Ugandan subjects. Seven different EV-related HPV types, including a putative new HPV, and two mucosal HPVs were detected in 25% (14 out of 56) of HIV-positive, in 10% (three out of 30) of HIV-negative conjunctival neoplasia samples, and rarely (0-1.6%) in control subjects.  ...[more]

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