Ontology highlight
ABSTRACT:
SUBMITTER: Levine JE
PROVIDER: S-EPMC2361693 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Levine John E JE Paczesny Sophie S Mineishi Shin S Braun Thomas T Choi Sung W SW Hutchinson Raymond J RJ Jones Dawn D Khaled Yasser Y Kitko Carrie L CL Bickley Daniel D Krijanovski Oleg O Reddy Pavan P Yanik Gregory G Ferrara James L M JL
Blood 20071127 4
Graft-versus-host disease (GVHD) is a principal cause of morbidity following allogeneic hematopoietic cell transplantation (HCT). Standard therapy for GVHD, high-dose steroids, results in complete responses (CRs) in 35% of patients. Because tumor necrosis factor-alpha (TNFalpha) is an important effector of experimental GVHD, we treated patients with new-onset GVHD with steroids plus the TNFalpha inhibitor etanercept on a previously reported pilot trial (n = 20) and a phase 2 trial (n = 41). We c ...[more]