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Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics.


ABSTRACT: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics.A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC).We identified 19 SNPs at 10 genes that were significantly related to lipids (p<0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively.The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.

SUBMITTER: Liao YC 

PROVIDER: S-EPMC2366941 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

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Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics.

Liao Yi-Chu YC   Lin Hsiu-Fen HF   Rundek Tanja T   Cheng Rong R   Hsi Edward E   Sacco Ralph L RL   Juo Suh-Hang Hank SH  

Clinical biochemistry 20071129 4-5


<h4>Objectives</h4>To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics.<h4>Design and methods</h4>A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholester  ...[more]

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