Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Y
PROVIDER: S-EPMC2366999 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Zhu Yong Y Stevens Richard G RG Leaderer Derek D Hoffman Aaron A Holford Theodore T Zhang Yawei Y Brown Heather N HN Zheng Tongzhang T
Breast cancer research and treatment 20070424 3
Three known non-synonymous polymorphisms (Ala394Thr, Ser471Leu and Pro690Ala) in the largest circadian gene, Neuronal PAS domain protein 2 (NPAS2), were genotyped in a breast cancer case-control study conducted in Connecticut, USA (431 cases and 476 controls). We found that women with the heterozygous Ala394Thr genotype were significantly associated with breast cancer risk compared to those with the common homozygous Ala394Ala (OR = 0.61, 0.46-0.81, P = 0.001). This is the first evidence demonst ...[more]