Ontology highlight
ABSTRACT:
SUBMITTER: Rohlfs RV
PROVIDER: S-EPMC2367501 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
BMC proceedings 20071218
Finding a genetic marker associated with a trait is a classic problem in human genetics. Recently, two-stage approaches have gained popularity in marker-trait association studies, in part because researchers hope to reduce the multiple testing problem by testing fewer markers in the final stage. We compared one two-stage family-based approach to an analogous single-stage method, calculating the empirical type I error rates and power for both methods using fully simulated data sets modeled on nuc ...[more]